Sample 126

Evaluation Instructions

Important: Models were tasked with extracting evidence from documents. Some outputs may be low quality and should be scored accordingly.

Your task: Compare the model-generated prediction (right panel) against the ground truth criteria (left panel).

Clean view: Shows formatted, readable text for easy comparison
Diff view: Highlights differences between ground truth and prediction
Raw view: Shows original unformatted text as it appears in the dataset

Evaluation scale (0-4):

0 = No match: Prediction is unrelated or contradicts the target criteria
1 = Poor match: Minimal overlap with ground truth, major errors or omissions
2 = Partial match: Some key elements captured, but notable gaps or inaccuracies
3 = Good match: Most elements correct, minor differences or formatting issues
4 = Excellent match: Essentially identical content, fully correct capture

Consider both content accuracy and completeness. Some predictions may be technically "correct" but incomplete or out of order.

Ground Truth

INCLUSION CRITERIA

1. Male and female subjects aged 18 to 45 years of age inclusive, and otherwise in good health as determined by medical history, physical examination, vital signs, ECGs and laboratory tests at screening.
2. Body weight between 50 and 120 kg, both inclusive, at screening.
3. Patients with papulo-pustular acne vulgaris (inflammatory acne) presenting with 20 to 100 facial inflammatory lesions (papules, pustules and nodules) at baseline, no more than 2 facial inflammatory nodules or cysts at screening and baseline, and a minimun number of 10 non-inflammatory facial lesions (open and closed comedones).
4. Patients who are candidates for systemic treatment and for whom in the opinion of the investigator, an appropriate previous treatment with topical anti-acne medication failed, or was not well tolerated, or is not indicated (e.g., due to large body surface area affected, e.g., on the back)Patients with Grade 3 (moderate) or Grade 4 (severe) IGA score assessed by the investigator at screening and baseline.

EXCLUSION CRITERIA

1. Appropriate wash out periods are required for investigational drugs, any oral/systemic treatment for acne, systemic or lesional injected (for acne) corticosteroids or systemic immunomodulators, any systemic hormonal treatments, previous treatment with biologics, oral retinoids (in particular isotretinoin) and any topical anti-acne treatment.
2. Previous surgical, physical (such as ThermaClear™), light (including blue or UV light, photodynamic therapy or laser therapy within 4 weeks prior to baselineUse of facial medium depth chemical peels (excluding home regimens) within 3 months prior to baseline.
3. Any other forms of acneAny severe, progressive or uncontrolled medical or psychiatric condition or other factors at randomization that in the judgment of the investigator prevents the patient from participating in the study.
4. Active systemic infections (other than common cold) during the 2 weeks prior to baseline.
5. History of immunodeficiency diseases, including a positive HIV (ELISA and Western blot) test result at screening.
6. Chronic infection with Hepatitis B or Hepatitis C virus.
7. Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive Human chorionic gonadotropin (HCG) laboratory test.
8. Sexually active males or women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using basic methods of contraception during dosing of study treatment.

Prediction

INCLUSION CRITERIA

1. Male and female subjects aged 18 to 45 years of age inclusive, and otherwise in good health as determined by medical history, physical examination, vital signs, ECGs, and laboratory tests at screening.
2. Body weight between 50 and 120 kg, both inclusive, at screening.
3. Patients with papulo-pustular acne vulgaris (inflammatory acne) presenting with 20 to 100 facial inflammatory lesions (papules, pustules, and nodules) at baseline, no more than 2 facial inflammatory nodules or cysts at screening and baseline, and a minimum number of 10 non-inflammatory facial lesions (open and closed comedones).
4. Patients who are candidates for systemic treatment and for whom, in the opinion of the investigator, an appropriate previous treatment with topical anti-acne medication failed, was not well tolerated, or is not indicated (e.g., due to large body surface area affected, e.g., on the back).
5. Patients with Grade 3 (moderate) or Grade 4 (severe) IGA score confirmed by central reading of standardized image capture (Visia® system) by an independent dermatologist at screening and by the investigator's clinical evaluation at baseline.

EXCLUSION CRITERIA

1. Appropriate washout periods are required for investigational drugs, any oral/systemic treatment for acne, systemic or lesional injected (for acne) corticosteroids or systemic immunomodulators, any systemic hormonal treatments, previous treatment with biologics, oral retinoids (in particular isotretinoin), and any topical anti-acne treatment.
2. Previous surgical, physical (such as ThermaClear™), light (including blue or UV light, photodynamic therapy), or laser therapy within 4 weeks prior to baseline.
3. Use of facial medium depth chemical peels (excluding home regimens) within 3 months prior to baseline.
4. Any other forms of acne.
5. Any severe, progressive, or uncontrolled medical or psychiatric condition or other factors at randomization that, in the judgment of the investigator, prevent the patient from participating in the study.
6. Active systemic infections (other than common cold) during the 2 weeks prior to baseline.
7. History of immunodeficiency diseases, including a positive HIV (ELISA and Western blot) test result at screening.
8. Chronic infection with Hepatitis B or Hepatitis C virus.
9. Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive Human chorionic gonadotropin (HCG) laboratory test.
10. Sexually active males or women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using basic methods of contraception during dosing of study treatment.
11. Patients receiving concomitant medication(s) that is/are known to inhibit OAT3 and that cannot be discontinued or replaced by safe alternative medication within 5 half-lives or 1 week (whichever is longer) prior to baseline and for the duration of the study.
12. Subjects with estimated Glomerular Filtration Rate (eGFR) < 60 mL/min/1.73 m².
13. History of drug or alcohol abuse within 6 months prior to screening.
14. Other protocol-defined inclusion/

EXCLUSION CRITERIA

1. may apply.